Primary Neural Degeneration in the Guinea Pig Cochlea After Reversible Noise-Induced Threshold Shift
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چکیده
منابع مشابه
Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss.
The classic view of sensorineural hearing loss (SNHL) is that the "primary" targets are hair cells, and that cochlear-nerve loss is "secondary" to hair cell degeneration. Our recent work in mouse and guinea pig has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of cochlear-...
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The effect of sound stimulation on phosphoinositide turnover was investigated in the inner ear of the guinea pig. The perilymphatic spaces of the cochlea were perfused with [(32)P]orthophosphate ((32)P(i)) and labeled lipids analyzed in the tissues of the lateral wall of the cochlea (stria vascularis and spiral ligament) and the basilar membrane (organ of Corti). Consistent with previous result...
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Potassium M currents play a role in stabilizing the resting membrane potential. These currents have previously been identified in several cell types, including sensory receptors. Given that maintaining membrane excitability is important for mechano-electrical transduction in the inner ear, the presence of M currents was investigated in outer hair cells isolated from the guinea pig hearing organ...
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ژورنال
عنوان ژورنال: Journal of the Association for Research in Otolaryngology
سال: 2011
ISSN: 1525-3961,1438-7573
DOI: 10.1007/s10162-011-0277-0